New discoveries from research into genetically modified mice and in 87 human tumors show that cannabis is not as a preventive anti-cancer green tea and other natural medicines against cancer, but has obvious effects resulting in the death of cancer cells, prevents metastasis and is an excellent complement to other therapies to affect the mechanism that gives resistance to a specific type of breast tumor to conventional therapies such as chemotherapy.
breast cancer called " ErbB2-Positive" is about a third of these cancers and is one of the most aggressive, with higher rates of recurrence and more difficult to attack through the use of therapies conventional. This is why we are constantly developing alternative therapies, but generally have a lower success rate. This problem led to the Autonomous University of Madrid, the Complutense University and the National Center for Biotechnology , all English institutes to investigate the relationship of these tumors with CB2 cannabinoid receptors after stimulation of these cannabinoid THC and JWH-133 .
For this article, published in the journal Molecular Cancer , were based on previous studies that proved the beneficial effect of the endocannabinoid system in various disorders such as pain, inflammation, eating disorders and brain damage, among others. But mainly on the evidence accumulated over the last decade on anti-proliferative effects and pro-apoptotic effects (cell death, in this case, cancer), anti-angiogenic and anti-invasive in different cell cultures and animal models of cancer.
Some of these studies are :
- Targeting the endocannabinoid system: to increase or decrease? (abstract in English)
- New strategies for the use of cannabinoid receptor agonists (full article in English).
- Cannabinoids for Cancer Treatment: Progress and Promise (complete English).
- Cannabinoids: potential anticancer agents (abstract in English).
There are two main types of endogenous receptors, ie outside the body, which are activated in the presence of cannabinoid CB1 is one which is present throughout the body for being connected to the nervous system whose stimulation produces the psychotropic effects that enjoy recreational users and / or medicinal effects how neuroprotective effect mentioned in a previous article or analgesia, eg paracetamol produced . The other is the CB2, which is related to specific parts of the immune system, which is less present in our body and it is related to anti-inflammatory responses and also neuroprotective in, for example, diseases such as Alzheimer's.
Because cancer cells have HER2-Positive CB2 receptors, cannabinoids have a direct effect on these without causing psychotropic effects that are generated to stimulate the CB1 or creating an effect very slight. In the case of the use of cannabinoid JWH-133, stimulates about 1 receptor CB1 and CB2 receptors in 200.
This study adds to the existing library of articles that demonstrate the beneficial properties of cannabis. In addition, like other studies, to achieve concrete results from the literature that grows daily with the current boom in the investigation of the endocannabinoid system, consequent to the rupture process of disinformation mechanism that generates all prejudices and preconceptions society and the scientific community to the detriment of everyone's health.
Hopefully
national universities contribute to recover the time lost because of the prohibitive laws in this field as promising as it is the investigation of cannabis and its medicinal effects.
Sources:
- Original article: Cannabinoids reduce the progression of breast cancer driven by ErbB2 through inhibition of Akt. in English. ( version. pdf)
- The marijuana has a "potent" antitumor specific breast cancer.
- components in marijuana could stop certain types of cancer.
- The marijuana has a "potent" antitumor .
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